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詳細(xì)解析ALZET滲透泵的使用優(yōu)點(diǎn)和工作機(jī)制
發(fā)布時(shí)間： 2022-07-19 點(diǎn)擊次數(shù)： 955次ALZET滲透泵已被用于數(shù)千項(xiàng)關(guān)于受控輸送各種實(shí)驗(yàn)藥物的影響的研究，包括肽、生長(zhǎng)因子、細(xì)胞因子、化療藥物、成癮藥物、激素、類固醇和抗體。由于ALZET滲透泵運(yùn)行的*機(jī)制，任何分子構(gòu)象的化合物都可以以受控的速率以可預(yù)測(cè)的方式輸送，而與它們的物理和化學(xué)特性無(wú)關(guān)。ALZET滲透泵的優(yōu)點(diǎn)：1、確保連續(xù)不斷的暴露在預(yù)定水平的測(cè)試藥物下；2、可以執(zhí)行短效期的蛋白質(zhì)及氨基酸給藥；3、提供了動(dòng)物慢性定量給藥的簡(jiǎn)單方法；4、解決了夜間及周末給藥的不便困擾；5、減少了對(duì)實(shí)驗(yàn)動(dòng)物的操作和應(yīng)激影響；6、足夠小到可以應(yīng)用到小鼠及年幼大鼠；7、可以向幾乎任何組織用藥；性價(jià)比很高的研究工具。ALZET滲透泵的工作機(jī)制：ALZET滲透泵的運(yùn)行主要是因?yàn)楸脙?nèi)滲透層的隔室與植入泵所在組織環(huán)境間存在的滲透壓差。滲透層的高滲透壓使組織中的水分通過(guò)泵外表面的半透膜流入泵中，當(dāng)水進(jìn)入滲透層時(shí)，它會(huì)壓縮柔性儲(chǔ)液罐，以受控的預(yù)定速率將測(cè)試溶液從泵中排出。由于無(wú)法重新填充壓縮儲(chǔ)液罐，因此泵僅設(shè)計(jì)為一次性使用。本產(chǎn)品的輸送速率是由泵外膜的透水性控制，因此泵的輸送曲線與分配的藥物制劑無(wú)關(guān)。各種分子構(gòu)型的藥物，包括電離藥物和大分子，可以在各種兼容的載體中以受控的速率連續(xù)分配。化合物的分子量或其物理和化學(xué)性質(zhì)與其通過(guò)ALZET滲透泵的輸送速率無(wú)關(guān)。ALZET滲透泵的容積輸送率在制造時(shí)是固定的。ALZET滲透泵具有0.11~10µL/hr之間的各種輸送速率和1天~6周之間的輸送持續(xù)時(shí)間。雖然泵的體積輸送速率是固定的，但可以通過(guò)改變用于填充泵儲(chǔ)液器的溶液或懸浮液中的藥劑濃度來(lái)實(shí)現(xiàn)不同的給藥速率。
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