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ALZET滲透泵在日常使用上擁有九大特點(diǎn)
發(fā)布時(shí)間： 2021-10-22 點(diǎn)擊次數(shù)： 916次ALZET滲透泵型控釋片一般由片芯和包衣膜兩部分組成，按照結(jié)構(gòu)特點(diǎn)，可將口服滲透泵制劑分為初級(jí)滲透泵和多室滲透泵兩類。初級(jí)滲透泵片芯中包含藥物和促滲透劑，包衣膜由高分子材料組成，包裹在片芯的表面。滲透泵片置于含水的環(huán)境中時(shí)，由于包衣膜內(nèi)外存在滲透壓差，水分通過包衣膜后形成藥物的溶液或混懸液，在包衣膜內(nèi)外滲透壓差的作用下，通過膜上的釋藥孔釋放。這種釋藥方式通常適用于在水中有一定溶解度的藥物。多室滲透泵制劑的片芯為雙層片，一層含有藥物及可溶解性輔料，另一層為遇水可膨脹的促滲透聚合物。這類滲透泵多適用于難溶性藥物滲透泵制劑的制備，釋藥過程由聚合物層膨脹產(chǎn)生推動(dòng)力而將藥物混懸液推出釋藥孔。ALZET滲透泵的使用優(yōu)點(diǎn)：1、體內(nèi)外相關(guān)性較好，可避免普通口服制劑造成的血藥濃度波動(dòng)較大的現(xiàn)象，提高用藥的安全性和有效性。2、ALZET滲透泵型控釋片以滲透壓為驅(qū)動(dòng)力，以零級(jí)釋放動(dòng)力學(xué)為釋藥特征，能夠在一定的時(shí)間范圍內(nèi)以恒定的釋藥速率釋放藥物，釋藥速率一般不受釋放介質(zhì)pH、攪拌速度以及胃腸蠕動(dòng)、食物等因素影響，能夠在較長時(shí)間內(nèi)維持恒速釋藥，減少用藥頻率。ALZET滲透泵產(chǎn)品特點(diǎn)：1、確保持續(xù)不間斷地均勻給藥；2、膠囊對(duì)半衰期短的藥物具有保護(hù)作用；3、減少了對(duì)實(shí)驗(yàn)動(dòng)物的操作和應(yīng)激影響；4、可以執(zhí)行短效期的蛋白質(zhì)及縮氨酸給藥；5、體積小，可應(yīng)用于小鼠或幼年大鼠等小動(dòng)物實(shí)驗(yàn)；6、確保將藥物準(zhǔn)確輸送到靶部位，可以向幾乎任何組織用藥；7、確保連續(xù)不斷得暴露在預(yù)定水平的測試藥物下；8、使用方便，一次實(shí)驗(yàn)僅需一次給藥，不再需要夜間或周末實(shí)驗(yàn)；9、避免因重復(fù)給藥給動(dòng)物造成的應(yīng)激，從而減少非實(shí)驗(yàn)因素對(duì)實(shí)驗(yàn)結(jié)果的影響。
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