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這些資料可以幫你詳細(xì)了解ALZET滲透泵
發(fā)布時(shí)間： 2021-07-21 點(diǎn)擊次數(shù)： 1006次ALZET滲透泵是在片芯外包被一層聚合物構(gòu)成的半透性衣膜，用激光在片劑衣膜層上開(kāi)一個(gè)或多個(gè)適宜大小的釋藥小孔而制成。口服后，胃腸道內(nèi)的水分通過(guò)半透膜進(jìn)入片芯，因滲透壓活性物質(zhì)使膜內(nèi)溶液呈高滲，膜內(nèi)外存在的滲透壓使水分繼續(xù)進(jìn)入膜內(nèi)，從而使藥物溶液或混懸的藥物從小孔泵出。常用的半透膜材料為醋酸纖維素。滲透壓活性物質(zhì)起調(diào)節(jié)藥室內(nèi)滲透壓的作用，其用量與零級(jí)釋藥時(shí)間長(zhǎng)短有關(guān)，常用氯化鈉、乳糖、果糖、葡萄糖、甘露糖等。ALZET滲透泵控釋制劑主要由藥物、半透膜材料、滲透壓活性物質(zhì)和推動(dòng)劑組成。它的體積只有膠囊大小，可植入實(shí)驗(yàn)動(dòng)物皮下或腹腔內(nèi)，直接或通過(guò)導(dǎo)管以µl/小時(shí)的速度持續(xù)準(zhǔn)確地輸注測(cè)試藥劑。這種輸注根據(jù)所使用的泵，可以在動(dòng)物清醒無(wú)束縛條件下長(zhǎng)持續(xù)6個(gè)星期。ALZET滲透泵的使用優(yōu)點(diǎn)：1、ALZET滲透泵型控釋片以滲透壓為驅(qū)動(dòng)力，以零級(jí)釋放動(dòng)力學(xué)為釋藥特征，能夠在一定的時(shí)間范圍內(nèi)以恒定的釋藥速率釋放藥物，釋藥速率一般不受釋放介質(zhì)pH、攪拌速度以及胃腸蠕動(dòng)、食物等因素影響，能夠在較長(zhǎng)時(shí)間內(nèi)維持恒速釋藥，減少用藥頻率。2、體內(nèi)外相關(guān)性較好，可避免普通口服制劑造成的血藥濃度波動(dòng)較大的現(xiàn)象，提高用藥的安全性和有效性。
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